Publication Beamlines Strategic Pillar
Colussi, Danielle M.; Grainger, Ryan; Noble, Megan; Lake, Taylor; Junop, Murray et al. (2025). Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal 27, 190-213. 10.1016/j.csbj.2024.12.007. [PDB: 8urg] CMCF-BM Health
Cottrell, Kevin M.; Briggs, Kimberly J.; Tsai, Alice; Tonini, Matthew R.; Whittington, Douglas A. et al. (2025). Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. Journal of Medicinal Chemistry 68(5) , 5097-5119. 10.1021/acs.jmedchem.4c03067. [PDB: 9n3o] CMCF-BM Health
Cregg, James; Edwards, Anne V.; Chang, Stephanie; Lee, Bianca J.; Knox, John E. et al. (2025). Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02314. [PDB: 9bg0, 9bg2, 9bg3, 9bg4, 9bg5, 9bg6, 9bg8, 9bga, 9bgb, 9bgc, 9bgd] CMCF-ID Health
Cregg, James; Pota, Kristof; Tomlinson, Aidan C. A.; Yano, Jason; Marquez, Abby et al. (2025). Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02313. [PDB: 9bfv, 9bfw] CMCF-ID Health
Ezekiel, Sean J.; Searle, Mackenzie; Park, Jaeok (2025). Engineering dimer mutants of human geranylgeranyl pyrophosphate synthase. PLoS ONE 20(1) , e0317437. 10.1371/journal.pone.0317437. [PDB: 9csl] CMCF-ID Health
Goncalves, Monica M.; Uday, Adwaith B.; Forrester, Taylor J. B.; Currie, S. Quinn W.; Kim, Angelina S. et al. (2025). Mechanism of allosteric activation in human mitochondrial ClpP protease. Proceedings of the National Academy of Sciences of the United States of America 122(16) . 10.1073/pnas.2419881122. [PDB: 9dqk, 9dql] CMCF-ID Health
Hu, Zhenyu; Klupt, Kody; Zechel, David L.; Jia, Zongchao; Howe, Graeme W. et al. (2025). Mining Thermophile Genomes for New PETases with Exceptional Thermostabilities using Sequence Similarity Networks. ChemBioChem . 10.1002/cbic.202500065. [PDB: 9eh6] CMCF-ID Environment
Ireland, Kendra A.; Kayrouz, Chase M.; Abbott, Marissa L.; Seyedsayamdost, Mohammad R.; Davis, Katherine M. et al. (2025). Structural and functional analysis of SAM-dependent N-methyltransferases involved in ovoselenol and ovothiol biosynthesis. Structure . 10.1016/j.str.2024.12.020. CMCF-ID Health
Kinzel, Olaf; Goldberg, Steven D.; Cummings, Maxwell D.; Gege, Christian; Steeneck, Christoph et al. (2025). Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis. Journal of Medicinal Chemistry 68(8) , 8713-8728. 10.1021/acs.jmedchem.5c00390. [PDB: 9n9l] CMCF-ID Health
Lee, Eunjeong; Tran, Norman; Redzic, Jasmina S.; Singh, Harmanpreet; Alamillo, Lorena et al. (2025). Identifying and controlling inactive and active conformations of a serine protease. Science Advances 11(15) . 10.1126/sciadv.adu7447. [PDB: 9bsh, 9bsm] CMCF-BM Health
Mendez, Alex; Bolling, Cydni; Taylor, Shane; Makumire, Stanley; Staker, Bart et al. (2025). Structure of Plasmodium vivax N-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy. Acta Crystallographica Section F:Structural Biology Communications 81(1) , 1-10. 10.1107/s2053230x24011348. [PDB: 5v0w] CMCF-ID Health
Miranda-Zaragoza, Beatriz; Huerta-Miranda, Guillermo A.; García-García, Wendy I.; Hernández-Álvarez, Elizabeth; Solano-Peralta, Alejandro et al. (2025). Structure-Function Relationship of the β-Hairpin of Thermus thermophilus HB27 Laccase. International Journal of Molecular Sciences 26(2) , 735. 10.3390/ijms26020735. [PDB: 9cpm] CMCF-ID Health
Nakhla, Mina C.; Comita, Janelle; Shapiro, Adam B.; Moussa, Samir H.; Chen, April et al. (2025). Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3. European Journal of Medicinal Chemistry 289, 117238. 10.1016/j.ejmech.2025.117238. [PDB: 9d17, 9d3y, 9d40, 9d4d] CMCF-ID Health
Sankhe, Safiétou; Fofana, Fatoumata G.; Heiba, Walid; Ogunyemi, Oludare M.; Masisi, Kabo et al. (2025). BioStruct-Africa’s capacity building workshops as a model for advancing the emerging community of structural biologists in Africa. Communications Chemistry 8(1) . 10.1038/s42004-025-01519-w. CMCF Health
Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] CMCF-BM Health