Publication Beamlines Strategic Pillar
Vinogradova, Maia; Gehling, Victor S; Gustafson, Amy; Arora, Shilpi; Tindell, Charles A et al. (2016). An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nature Chemical Biology 12(7) , 531-538. 10.1038/nchembio.2085. [PDB: 5ceh] CMCF-ID Health
Hobbs, Joanne K.; Lee, Seunghyae M.; Robb, Melissa; Hof, Fraser; Barr, Christopher et al. (2016). KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate. Proceedings of the National Academy of Sciences of the United States of America 113(22) , 6188-6193. 10.1073/pnas.1524214113. [PDB: 5fpx, 5fpz] CMCF-ID Materials
Nicklisch, Sascha C. T.; Rees, Steven D.; McGrath, Aaron P.; Gökirmak, Tufan; Bonito, Lindsay T. et al. (2016). Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure. Science advances 2(4) , e1600001-e1600001. 10.1126/sciadv.1600001. [PDB: 4xwk] CMCF-ID Environment
Taylor, Alexander M.; Côté, Alexandre; Hewitt, Michael C.; Pastor, Richard; Leblanc, Yves et al. (2016). Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). ACS Medicinal Chemistry Letters 7(5) , 531-536. 10.1021/acsmedchemlett.6b00075. [PDB: 5i83, 5i86] CMCF-ID Health
Gorelik, Alexei; Illes, Katalin; Heinz, Leonhard X.; Superti-Furga, Giulio; Nagar, Bhushan et al. (2016). Crystal structure of mammalian acid sphingomyelinase. Nature Communications 7(1) . 10.1038/ncomms12196. [PDB: 5fi9, 5fib, 5fic, 5hqn] CMCF-BM, CMCF-ID Health
Caldwell, Shane J.; Huang, Yue; Berghuis, Albert M. (2016). Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia. Structure 24(6) , 935-945. 10.1016/j.str.2016.04.002. [PDB: 5byl, 5iqa, 5iqb, 5iqc, 5iqd, 5iqe, 5iqg, 5iqh] CMCF-ID Health
Tebben, Andrew J.; Ruzanov, Maxim; Gao, Mian; Xie, Dianlin; Kiefer, Susan E. et al. (2016). Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity. Acta Crystallographica Section D: Structural Biology 72(5) , 658-674. 10.1107/s2059798316003624. [PDB: 5e8u] CMCF-ID Health
Liu, Longbin; Lee, Matthew R.; Kim, Joseph L.; Whittington, Douglas A.; Bregman, Howard et al. (2016). Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling. Bioorganic and Medicinal Chemistry 24(10) , 2215-2234. 10.1016/j.bmc.2016.03.055. [PDB: 5fd2] CMCF-ID Health
Mann, Paul A.; Müller, Anna; Wolff, Kerstin A.; Fischmann, Thierry; Wang, Hao et al. (2016). Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets. PLoS Pathogens 12(5) , e1005585. 10.1371/journal.ppat.1005585. [PDB: 5enz] CMCF-ID Health
Gruninger, Robert J.; Cote, Chris; McAllister, Tim A.; Abbott, D. Wade (2016). Contributions of a unique β-clamp to substrate recognition illuminates the molecular basis of exolysis in ferulic acid esterases. Biochemical Journal 473(7) , 839-849. 10.1042/bj20151153. [PDB: 5cxu, 5cxx] CMCF-ID Agriculture
Roach, Elyse J.; Wroblewski, Charles; Seidel, Laura; Berezuk, Alison M.; Brewer, Dyanne et al. (2016). Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling. Journal of Bacteriology 198(11) , 1683-1693. 10.1128/jb.00969-15. [PDB: 5dko] CMCF-ID Agriculture
Vashchenko, Ganna; Das, Samir; Moon, Kyung-Mee; Rogalski, Jason C.; Taves, Matthew D. et al. (2016). Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein. Journal of Biological Chemistry 291(21) , 11300-11312. 10.1074/jbc.m116.714378. [PDB: 5hgc] CMCF-ID Health
Bloudoff, Kristjan; Alonzo, Diego A.; Schmeing, T. Martin (2016). Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases. Cell Chemical Biology 23(3) , 331-339. 10.1016/j.chembiol.2016.02.012. [PDB: 5du9, 5dua] CMCF-ID Health
Noach, Ilit; Pluvinage, Benjamin; Laurie, Cassandra; Abe, Kento T.; Alteen, Matthew G. et al. (2016). The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium perfringens. Journal of Molecular Biology 428(16) , 3253-3265. 10.1016/j.jmb.2016.03.020. [PDB: 5fqe, 5fqg, 5fqh, 5fr0] CMCF-ID Health
Lyons, Bronwyn; Ravulapalli, Ravikiran; Lanoue, Jason; Lugo, Miguel R.; Dutta, Debajyoti et al. (2016). Scabin, a Novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies. Journal of Biological Chemistry 291(21) , 11198-11215. 10.1074/jbc.m115.707653. [PDB: 5daz, 5ewk, 5ewy] CMCF-ID Health