Publication Beamlines Strategic Pillar
Freibert, Sven-A.; Boniecki, Michal T.; Stümpfig, Claudia; Schulz, Vinzent; Krapoth, Nils et al. (2021). N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization. Nature Communications 12(1) . 10.1038/s41467-021-27122-w. CMCF-ID Health
Gavai, Ashvinikumar V.; Norris, Derek; Delucca, George; Tortolani, David; Tokarski, John S. et al. (2021). Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design. Journal of Medicinal Chemistry 64(19) . 10.1021/acs.jmedchem.1c00625. [PDB: 5s9r] CMCF-ID Health
Gerak, Chloe A.N.; Cho, Sophia Y.; Kolesnikov, Maxim; Okon, Mark; Murphy, Michael E.P. et al. (2021). Biophysical characterization of the ETV6 PNT domain polymerization interfaces. Journal of Biological Chemistry 296, 100284. 10.1016/j.jbc.2021.100284. [PDB: 7ju2] CMCF-BM Health
Golkar, Tolou; Bassenden, Angelia V.; Maiti, Krishnagopal; Arya, Dev P.; Schmeing, T. Martin et al. (2021). Structural basis for plazomicin antibiotic action and resistance. Communications Biology 4(1) . 10.1038/s42003-021-02261-4. [PDB: 6vou, 7lh5] CMCF-ID Health
Grochulski, Pawel; Labiuk, Shaunivan (2021). Review of health research at the Canadian Light Source. Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 499, 70-76. 10.1016/j.nimb.2021.05.003. BIOXAS, BMIT, CMCF, MID-IR, SM, SXRMB, VESPERS Health
Guo, Shuaiqi; Vance, Tyler D. R.; Zahiri, Hossein; Eves, Robert; Stevens, Corey et al. (2021). Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation. mBio 12(2) . 10.1128/mbio.00130-21. [PDB: 6x7j, 6x7t, 6x7y, 6x7z, 6x8a, 6x8d, 6x8y, 6x95, 6x9m, 6x9p, 6xa5, 6xaq] CMCF-ID Health
Higgins, Melanie A.; Tegl, Gregor; MacDonald, Spencer S.; Arnal, Gregory; Brumer, Harry et al. (2021). N-Glycan Degradation Pathways in Gut- and Soil-Dwelling Actinobacteria Share Common Core Genes. ACS Chemical Biology 16(4) . 10.1021/acschembio.0c00995. [PDB: 7lqx, 7lr1] CMCF-ID Health
Hill, Matthew D.; Quesnelle, Claude; Tokarski, John; Fang, Haiquan; Fanslau, Carolynn et al. (2021). Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype. Bioorganic and Medicinal Chemistry Letters 51, 128376. 10.1016/j.bmcl.2021.128376. [PDB: 7mce] CMCF-ID Health
Huang, Ji; Fraser, Marie E. (2021). Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase. Acta Crystallographica Section D: Structural Biology 77(3) , 357-368. 10.1107/s2059798321000334. [PDB: 7jj0, 7jkr] CMCF-ID Health
Hu, Carol H.; Neissel Valente, Meriah W.; Halpern, O. Scott; Jusuf, Sutjano; Khan, Javed A. et al. (2021). Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO). Bioorganic and Medicinal Chemistry Letters 42, 128010. 10.1016/j.bmcl.2021.128010. [PDB: 7lag, 7lan] CMCF-ID Health
Keylor, Mitchell H.; Gulati, Anmol; Kattar, Solomon D.; Johnson, Rebecca E.; Chau, Ryan W. et al. (2021). Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. Journal of Medicinal Chemistry 65(1) , 838-856. 10.1021/acs.jmedchem.1c01968. [PDB: 7suh] CMCF-ID Health
Kuduk, Scott D.; Stoops, Bart; Alexander, Richard; Lam, Angela M.; Espiritu, Christine et al. (2021). Identification of a new class of HBV capsid assembly modulator. Bioorganic and Medicinal Chemistry Letters 39, 127848. 10.1016/j.bmcl.2021.127848. [PDB: 7k5m] CMCF-ID Health
Kumar, Amit; Paul, Marilyn; Panda, Manoranjan; Jayaram, Shruthi; Kalidindi, Narasimharaju et al. (2021). Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3. Glycobiology 31(10) . 10.1093/glycob/cwab072. [PDB: 7cxa] CMCF-ID Health
Langston, Steven P.; Grossman, Stephen; England, Dylan; Afroze, Roushan; Bence, Neil et al. (2021). Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. Journal of Medicinal Chemistry 64(5) . 10.1021/acs.jmedchem.0c01491. [PDB: 6xog, 6xoh] CMCF-ID Health
Li, Franco K.K.; Gale, Robert T.; Petrotchenko, Evgeniy V.; Borchers, Christoph H.; Brown, Eric D. et al. (2021). Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis. Journal of Structural Biology 213(2) , 107733. 10.1016/j.jsb.2021.107733. [PDB: 6xh9, 6xhk, 6xhp, 6xhq, 6xhr, 6xhs, 6xht] CMCF-ID Health