| Spergel, Steven H.; Mertzman, Michael E.; Kempson, James; Guo, Junqing; Stachura, Sylwia et al. (2019). Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Medicinal Chemistry Letters 10(3) , 306-311. 10.1021/acsmedchemlett.8b00508. [PDB: 6ny4] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Almawi, Ahmad W; Scotland, Michelle K; Randall, Justin R; Liu, Linda; Martin, Heather K et al. (2019). Binding of the regulatory domain of MutL to the sliding β-clamp is species specific. Nucleic Acids Research 47(9) . 10.1093/nar/gkz115. [PDB: 6e8d, 6e8e] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
| Sengupta, Shomit; Giaime, Emilie; Narayan, Sridhar; Hahm, Seung; Howell, Jessica et al. (2019). Discovery of NV-5138, the first selective Brain mTORC1 activator. Scientific Reports 9(1) , 4107. 10.1038/s41598-019-40693-5. [PDB: 6n0m] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Simonetta, Kyle R.; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E.; Padovani, Chris et al. (2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 10(1) , 1402. 10.1038/s41467-019-09358-9. [PDB: 6m91, 6m92, 6m93, 6m94] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Raman, Swetha; Beilschmidt, Melissa; To, Minh; Lin, Kevin; Lui, Francine et al. (2019). Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America 116(14) , 6812-6817. 10.1073/pnas.1817246116. [PDB: 6o39, 6o3a] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Doyle, L.; Mallette, E.; Kimber, M.S. (2019). Escherichia coli KpsC, N-terminal domain. Protein Data Bank: 6mgc. |
CMCF-ID |
PDB Deposition |
Health |
| Caveney, N.A.; Strynadka, N.C.J.; Caballero, G.; Worrall, L.J. (2019). Crystal structure of E. coli PBP5-meropenem. Protein Data Bank: 6ntz. |
CMCF-BM |
PDB Deposition |
Health |
| Kiefer, J.R.; Vinogradova, M.; Liang, J.; Zhang, B.; Ortwine, D.F. et al. (2019). Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa. Protein Data Bank: 6dfn. |
CMCF-ID |
PDB Deposition |
Health |
| Moss, D.L.; Park, H.W.; Mettu, R.R.; Landry, S.J. (2019). Pseudomonas exotoxin A domain III T18H477L. Protein Data Bank: 6edg. |
CMCF-ID |
PDB Deposition |
Health |
| Wei, Yong; Xiong, Zi Jian; Li, Jun; Zou, Chunxia; Cairo, Christopher W. et al. (2019). Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters. Communications Biology 2(1) . 10.1038/s42003-018-0262-9. [PDB: 6e7o] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Nation, C.; Pizarro, J.C. (2019). Candida albicans Hsp90 nucleotide binding domain in complex with radicicol. Protein Data Bank: 6cjp. |
CMCF-ID |
PDB Deposition |
Health |
| Nation, C.; Pizarro, J.C. (2019). Candida albicans Hsp90 nucleotide binding domain in complex with radicicol. Protein Data Bank: 6cjl. |
CMCF-ID |
PDB Deposition |
Health |
| Whitesell, Luke; Robbins, Nicole; Huang, David S.; McLellan, Catherine A.; Shekhar-Guturja, Tanvi et al. (2019). Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications 10(1) , 402. 10.1038/s41467-018-08248-w. [PDB: 6cjl, 6cjp] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Moore, S.A.; Marshall, J.D.; Anderson, D.H. (2019). Structure of the Bovine p85a BH domain R228E mutant. Protein Data Bank: 6mrp. |
CMCF-BM |
PDB Deposition |
Health |
| Mark, B.L.; Vadlamani, G. (2019). Carbapenemase VCC-1 from Vibrio cholerae N14-02106. Protein Data Bank: 6mk6. |
CMCF-BM |
PDB Deposition |
Health |