Publication Beamlines Strategic Pillar
Bertwistle, Drew; Vogt, Linda; Aamudalapalli, Hari Babu; Palmer, David R. J.; Sanders, David A. R. et al. (2014). Purification, crystallization and room-temperature X-ray diffraction of inositol dehydrogenase LcIDH2 fromLactobacillus caseiBL23. Acta Crystallographica Section F Structural Biology and Crystallization Communications 70(7) , 979-983. 10.1107/s2053230x14011595. CMCF-ID Health
Blattner, Claudia; Lee, Jeong Hyun; Sliepen, Kwinten; Derking, Ronald; Falkowska, Emilia et al. (2014). Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity 40(5) , 669-680. 10.1016/j.immuni.2014.04.008. [PDB: 4nug] CMCF-ID Health
De Schutter, Joris W.; Park, Jaeok; Leung, Chun Yuen; Gormley, Patrick; Lin, Yih-Shyan et al. (2014). Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases. Journal of Medicinal Chemistry 57(13) , 5764-5776. 10.1021/jm500629e. [PDB: 4lpg, 4lph] CMCF-ID Health
Elliott, J.Michael; Ultsch, Mark; Lee, Joshua; Tong, Raymond; Takeda, Kentaro et al. (2014). Antiparallel Conformation of Knob and Hole Aglycosylated Half-Antibody Homodimers Is Mediated by a CH2–CH3 Hydrophobic Interaction. Journal of Molecular Biology 426(9) , 1947-1957. 10.1016/j.jmb.2014.02.015. [PDB: 4nqt] CMCF-ID Health
Fodje, Michel; Grochulski, Pawel; Janzen, Kathryn; Labiuk, Shaunivan; Gorin, James et al. (2014). 08B1-1: an automated beamline for macromolecular crystallography experiments at the Canadian Light Source. Journal of Synchrotron Radiation 21(3) , 633-637. 10.1107/s1600577514005578. CMCF-BM Materials
Grishin, Andrey M.; Condos, Tara E.C.; Barber, Kathryn R.; Campbell-Valois, François-Xavier; Parsot, Claude et al. (2014). Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG. Structure 22(6) , 878-888. 10.1016/j.str.2014.04.010. [PDB: 4q5e, 4q5h] CMCF-ID Health
Gruninger, Robert J.; Thibault, John; Capeness, Michael J.; Till, Robert; Mosimann, Steven C. et al. (2014). Structural and Biochemical Analysis of a Unique Phosphatase from Bdellovibrio bacteriovorus Reveals Its Structural and Functional Relationship with the Protein Tyrosine Phosphatase Class of Phytase. PLoS ONE 9(4) , e94403. 10.1371/journal.pone.0094403. [PDB: 4nx8] CMCF-ID Health
Higgins, Melanie A.; Suits, Michael D.; Marsters, Candace; Boraston, Alisdair B. (2014). Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus pneumoniae. Journal of Molecular Biology 426(7) , 1469-1482. 10.1016/j.jmb.2013.12.006. [PDB: 4c21, 4c22] CMCF-BM Health
Johnson, Ted W.; Richardson, Paul F.; Bailey, Simon; Brooun, Alexei; Burke, Benjamin J. et al. (2014). Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations. Journal of Medicinal Chemistry 57(11) , 4720-4744. 10.1021/jm500261q. [PDB: 4ctb] CMCF-ID Health
Khozeimeh Sarbisheh, Elaheh; Green, Jennifer C.; Müller, Jens (2014). Isomerization of an Enantiomerically Pure Phosphorus-Bridged [1]Ferrocenophane. Organometallics 33(13) , 3508-3513. 10.1021/om500424m. CMCF-BM Materials
King, Dustin T.; Lameignere, Emilie; Strynadka, Natalie C.J. (2014). Structural Insights into the Lipoprotein Outer Membrane Regulator of Penicillin-binding Protein 1B. Journal of Biological Chemistry 289(27) , 19245-19253. 10.1074/jbc.m114.565879. [PDB: 4q6l, 4q6v, 4q6z] CMCF-BM Health
Loewen, Peter C.; Carpena, Xavi; Vidossich, Pietro; Fita, Ignacio; Rovira, Carme et al. (2014). An Ionizable Active-Site Tryptophan Imparts Catalase Activity to a Peroxidase Core. Journal of the American Chemical Society 136(20) , 7249-7252. 10.1021/ja502794e. [PDB: 5syh, 5syk] CMCF-ID Materials
Oh, Angela; Ho, Yen-Ching; Zak, Mark; Liu, Yongbo; Chen, Xukun et al. (2014). Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase. ChemBioChem 15(8) , 1121-1130. 10.1002/cbic.201402023. [PDB: 4o0z, 4o10] CMCF-ID Health
Persch, Elke; Bryson, Steve; Todoroff, Nickolay K.; Eberle, Christian; Thelemann, Jonas et al. (2014). Binding to Large Enzyme Pockets: Small-Molecule Inhibitors of Trypanothione Reductase. ChemMedChem , 1880-1891. 10.1002/cmdc.201402032. [PDB: 4nev] CMCF-BM Health
Recht, Michael I.; Sridhar, Vandana; Badger, John; Bounaud, Pierre-Yves; Logan, Cheyenne et al. (2014). Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography. Journal of Biomolecular Screening 19(4) , 497-507. 10.1177/1087057113516493. [PDB: 4mrw, 4mrz, 4ms0, 4msa, 4msc, 4mse] CMCF-ID Health