Publication Beamlines Strategic Pillar
Abbas, Yazan M.; Laudenbach, Beatrice Theres; Martínez-Montero, Saúl; Cencic, Regina; Habjan, Matthias et al. (2017). Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations. Proceedings of the National Academy of Sciences of the United States of America 114(11) , E2106-E2115. 10.1073/pnas.1612444114. [PDB: 5udi, 5udj, 5udk, 5udl] CMCF-ID
Cook, Jonathan D.; Sultana, Azmiri; Lee, Jeffrey E. (2017). Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment. Proceedings of the National Academy of Sciences of the United States of America 114(14) , E2929-E2936. 10.1073/pnas.1617993114. [PDB: 5t96, 5t9y] CMCF-ID
Duclos, Franck; Abell, Lynn M.; Harden, David G.; Pike, Kristen; Nowak, Kimberly et al. (2017). Triazolopyrimidines identified as reversible myeloperoxidase inhibitors. MedChemComm 8(11) , 2093-2099. 10.1039/c7md00268h. [PDB: 5wdj] CMCF-ID
Eastman, Kyle J.; Parcella, Kyle; Yeung, Kap-Sun; Grant-Young, Katharine A.; Zhu, Juliang et al. (2017). The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. MedChemComm 8(4) , 796-806. 10.1039/c6md00636a. [PDB: 5twn] CMCF-ID
El-Halfawy, Omar M.; Klett, Javier; Ingram, Rebecca J.; Loutet, Slade A.; Murphy, Michael E. P. et al. (2017). Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. mBio 8(2) , e00225-17. 10.1128/mbio.00225-17. [PDB: 5ixg, 5ixh] CMCF-ID
Gorelik, Alexei; Liu, Fangyu; Illes, Katalin; Nagar, Bhushan (2017). Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition. Journal of Biological Chemistry 292(17) , 7087-7094. 10.1074/jbc.m116.769273. [PDB: 5tcd, 5udy] CMCF-ID
Haft, Daniel H.; Pierce, Phillip G.; Mayclin, Stephen J.; Sullivan, Amy; Gardberg, Anna S. et al. (2017). Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors. Scientific Reports 7(1) . 10.1038/srep41074. [PDB: 3t7c] CMCF-ID
Jha, Vikash; Ling, Hong (2017). Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa. DNA Repair 49, 43-50. 10.1016/j.dnarep.2016.11.001. [PDB: 5t14] CMCF-ID
McGregor, Nicholas; Yin, Victor; Tung, Ching-Chieh; Van Petegem, Filip; Brumer, Harry et al. (2017). Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases. Plant Journal 89(4) , 651-670. 10.1111/tpj.13421. [PDB: 5dze, 5dzf, 5sv8] CMCF-ID
McPhail, Jacob A.; Ottosen, Erik H.; Jenkins, Meredith L.; Burke, John E. (2017). The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3. Structure 25(1) , 121-131. 10.1016/j.str.2016.11.016. [PDB: 5tdq] CMCF-ID
Moen, Spencer O.; Edwards, Thomas E.; Dranow, David M.; Clifton, Matthew C.; Sankaran, Banumathi et al. (2017). Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms. Scientific Reports 7(1) . 10.1038/s41598-017-00367-6. [PDB: 3tze] CMCF-ID
Noach, Ilit; Ficko-Blean, Elizabeth; Pluvinage, Benjamin; Stuart, Christopher; Jenkins, Meredith L. et al. (2017). Recognition of protein-linked glycans as a determinant of peptidase activity. Proceedings of the National Academy of Sciences of the United States of America 114(5) , E679-E688. 10.1073/pnas.1615141114. [PDB: 5kd5, 5kd8, 5kdn, 5kdu, 5kdv, 5kdw, 5kdx] CMCF-BM, CMCF-ID
Park, Jaeok; Leung, Chun Yuen; Matralis, Alexios N.; Lacbay, Cyrus M.; Tsakos, Michail et al. (2017). Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. Journal of Medicinal Chemistry 60(5) , 2119-2134. 10.1021/acs.jmedchem.6b01888. [PDB: 5juz, 5jv1] CMCF-ID
Park, Jaeok; Zielinski, Michal; Magder, Alexandr; Tsantrizos, Youla S.; Berghuis, Albert M. et al. (2017). Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nature Communications 8(1) . 10.1038/ncomms14132. [PDB: 5ja0] CMCF-ID
Planken, Simon; Behenna, Douglas C.; Nair, Sajiv K.; Johnson, Theodore O.; Nagata, Asako et al. (2017). Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR. Journal of Medicinal Chemistry 60(7) , 3002-3019. 10.1021/acs.jmedchem.6b01894. [PDB: 5ugc] CMCF-ID