Bagal, Sharan K.; Andrews, Mark; Bechle, Bruce M.; Bian, Jianwei; Bilsland, James et al. (2018). Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry 61(15) , 6779-6800. 10.1021/acs.jmedchem.8b00633. [PDB: 6dkb] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Bagal, Sharan K.; Omoto, Kiyoyuki; Blakemore, David C.; Bungay, Peter J.; Bilsland, James G. et al. (2018). Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors. Journal of Medicinal Chemistry 62(1) , 247-265. 10.1021/acs.jmedchem.8b00280. [PDB: 6d20] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Baral, Pravas Kumar; Swayampakula, Mridula; Aguzzi, Adriano; James, Michael N. G. (2018). Structural characterization of
POM
6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion. FEBS Journal 285(9) , 1701-1714. 10.1111/febs.14438. [PDB: 6aq7] |
CMCF-BM |
Peer-Reviewed Article |
Health |
Blank, Matthew L.; Parker, Michelle L.; Ramaswamy, Raghavendran; Powell, Cameron J.; English, Elizabeth D. et al. (2018). A
Toxoplasma gondii
locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions. Molecular Microbiology 108(5) , 519-535. 10.1111/mmi.13947. [PDB: 6bxr, 6bxs] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Bonday, Zahid Q.; Cortez, Guillermo S.; Grogan, Michael J.; Antonysamy, Stephen; Weichert, Ken et al. (2018). LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Medicinal Chemistry Letters 9(7) , 612-617. 10.1021/acsmedchemlett.8b00014. [PDB: 6ckc] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Bonnick, Patrick; Blanc, Lauren; Vajargah, Shahrzad Hosseini; Lee, Chang-Wook; Sun, Xiaoqi et al. (2018). Insights into Mg2+ Intercalation in a Zero-Strain Material: Thiospinel MgxZr2S4. Chemistry of Materials 30(14) , 4683-4693. 10.1021/acs.chemmater.8b01345. |
CMCF-BM |
Peer-Reviewed Article |
Materials |
Dong, Cheng; Zhang, Heng; Li, Li; Tempel, Wolfram; Loppnau, Peter et al. (2018). Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nature Chemical Biology 14(5) , 466-473. 10.1038/s41589-018-0036-1. [PDB: 6cdc] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Gebai, Ahmad; Gorelik, Alexei; Li, Zixian; Illes, Katalin; Nagar, Bhushan et al. (2018). Structural basis for the activation of acid ceramidase. Nature Communications 9(1) . 10.1038/s41467-018-03844-2. [PDB: 5u7z, 5u81, 5u84] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Gorelik, Alexei; Randriamihaja, Antsa; Illes, Katalin; Nagar, Bhushan (2018). Structural basis for nucleotide recognition by the ectoenzyme
CD
203c. FEBS Journal 285(13) . 10.1111/febs.14489. [PDB: 6c01, 6c02] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Guo, Shuaiqi; Langelaan, David N.; Phippen, Sean W.; Smith, Steven P.; Voets, Ilja K. et al. (2018). Conserved structural features anchor biofilm‐associated
RTX
–adhesins to the outer membrane of bacteria. FEBS Journal 285(10) , 1812-1826. 10.1111/febs.14441. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Gusev, Dmitry G.; Spasyuk, Denis M. (2018). Revised Mechanisms for Aldehyde Disproportionation and the Related Reactions of the Shvo Catalyst. ACS Catalysis 8(8) , 6851-6861. 10.1021/acscatal.8b01153. |
CMCF-BM |
Peer-Reviewed Article |
Materials |
Hettle, Andrew G.; Vickers, Chelsea; Robb, Craig S.; Liu, Feng; Withers, Stephen G. et al. (2018). The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme. Structure 26(5) , 747-758.e4. 10.1016/j.str.2018.03.012. [PDB: 6b0k] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Huang, Christine S.; Oberbeck, Nina; Hsiao, Yi-Chun; Liu, Peter; Johnson, Adam R. et al. (2018). Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure 26(5) , 767-777.e5. 10.1016/j.str.2018.04.002. [PDB: 5wni] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Imkeller, Katharina; Scally, Stephen W.; Bosch, Alexandre; Martí, Gemma Pidelaserra; Costa, Giulia et al. (2018). Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science 360(6395) , 1358-1362. 10.1126/science.aar5304. [PDB: 6d01, 6d11] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Jacques, Benoit; Coinçon, Mathieu; Sygusch, Jurgen (2018). Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. Journal of Biological Chemistry 293(20) , 7737-7753. 10.1074/jbc.ra117.001098. [PDB: 5ucn, 5ucp, 5ucs, 5ucz, 5ud0, 5ud1, 5ud2] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |