Gorelik, Alexei; Heinz, Leonhard X.; Illes, Katalin; Superti-Furga, Giulio; Nagar, Bhushan et al. (2016). Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity. Journal of Biological Chemistry 291(46) , 24054-24064. 10.1074/jbc.m116.755801. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Lugo, Miguel R.; Ravulapalli, Ravikiran; Dutta, Debajyoti; Rod Merrill, A. (2016). Structural variability of C3larvin toxin. Intrinsic dynamics of the α/β fold of the C3-like group of mono-ADP-ribosyltransferase toxins. Journal of Biomolecular Structure and Dynamics , 2537-2560. 10.1080/07391102.2015.1123189. [PDB: 5dzq] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Chung, Ho-Ryun; Xu, Chao; Fuchs, Alisa; Mund, Andreas; Lange, Martin et al. (2016). PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. eLife 5, e10607. 10.7554/elife.10607. [PDB: 3o70] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Hendsbee, Arthur D.; Sun, Jon-Paul; Law, Wai Kit; Yan, He; Hill, Ian G. et al. (2016). Synthesis, Self-Assembly, and Solar Cell Performance of N-Annulated Perylene Diimide Non-Fullerene Acceptors. Chemistry of Materials 28(19) , 7098-7109. 10.1021/acs.chemmater.6b03292. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Materials |
Jones, Michael D.; Chan, Anson C. K.; Nomellini, John F.; Murphy, Michael E. P.; Smit, John et al. (2016). Surface-layer protein fromCaulobacter crescentus: expression, purification and X-ray crystallographic analysis. Acta Crystallographica Section F:Structural Biology Communications 72(9) , 677-680. 10.1107/s2053230x16011638. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Beyrakhova, Ksenia A.; van Straaten, Karin; Li, Lei; Boniecki, Michal T.; Anderson, Deborah H. et al. (2016). Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila. Journal of Biological Chemistry 291(30) , 15767-15777. 10.1074/jbc.m115.708701. [PDB: 5fia, 5jg4] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Bryson, Steve; Thomson, Christy A.; Risnes, Louise F.; Dasgupta, Somnath; Smith, Kenneth et al. (2016). Structures of Preferred Human IgV Genes–Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation. Journal of Immunology 196(11) , 4723-4730. 10.4049/jimmunol.1402890. [PDB: 4hh9, 4hha] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Watterson, Scott H.; De Lucca, George V.; Shi, Qing; Langevine, Charles M.; Liu, Qingjie et al. (2016). Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. Journal of Medicinal Chemistry 59(19) , 9173-9200. 10.1021/acs.jmedchem.6b01088. [PDB: 5t18] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Richter, Jeremy M.; Cheney, Daniel L.; Bates, J. Alex; Wei, Anzhi; Luettgen, Joseph M. et al. (2016). Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Medicinal Chemistry Letters 8(1) , 67-72. 10.1021/acsmedchemlett.6b00375. [PDB: 5tqe] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Movahedin, Mohammadreza; Brooks, Teresa M; Supekar, Nitin T; Gokanapudi, Naveen; Boons, Geert-Jan et al. (2016). Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen. Glycobiology , 677-687. 10.1093/glycob/cww131. [PDB: 5t6p, 5t78] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Moustakim, Moses; Clark, Peter G. K.; Trulli, Laura; Fuentes de Arriba, Angel L.; Ehebauer, Matthias T. et al. (2016). Discovery of a PCAF Bromodomain Chemical Probe. Angewandte Chemie - International Edition 56(3) , 827-831. 10.1002/anie.201610816. [PDB: 5tpx] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Parker, Michelle L.; Houston, Simon; Wetherell, Charmaine; Cameron, Caroline E.; Boulanger, Martin J. et al. (2016). The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains. PLoS ONE 11(11) , e0166274. 10.1371/journal.pone.0166274. [PDB: 5jir] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Hewitt, Stephen Nakazawa; Dranow, David M.; Horst, Benjamin G.; Abendroth, Jan A.; Forte, Barbara et al. (2016). Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. ACS Infectious Diseases 3(1) , 34-44. 10.1021/acsinfecdis.6b00078. [PDB: 4wi1, 5ifu] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Crawford, Terry D.; Romero, F. Anthony; Lai, Kwong Wah; Tsui, Vickie; Taylor, Alexander M. et al. (2016). Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Journal of Medicinal Chemistry 59(23) , 10549-10563. 10.1021/acs.jmedchem.6b01022. [PDB: 5ktw] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Bloudoff, Kristjan; Fage, Christopher D.; Marahiel, Mohamed A.; Schmeing, T. Martin (2016). Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis. Proceedings of the National Academy of Sciences of the United States of America 114(1) , 95-100. 10.1073/pnas.1614191114. [PDB: 5t3e] |
CMCF-ID |
Peer-Reviewed Article |
Health |