Getlik, Matthäus; Smil, David; Zepeda-Velázquez, Carlos; Bolshan, Yuri; Poda, Gennady et al. (2016). Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Journal of Medicinal Chemistry 59(6) , 2478-2496. 10.1021/acs.jmedchem.5b01630. [PDB: 5eam, 5eap] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Gorelik, Alexei; Heinz, Leonhard X.; Illes, Katalin; Superti-Furga, Giulio; Nagar, Bhushan et al. (2016). Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity. Journal of Biological Chemistry 291(46) , 24054-24064. 10.1074/jbc.m116.755801. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Gorelik, Alexei; Illes, Katalin; Heinz, Leonhard X.; Superti-Furga, Giulio; Nagar, Bhushan et al. (2016). Crystal structure of mammalian acid sphingomyelinase. Nature Communications 7(1) . 10.1038/ncomms12196. [PDB: 5fi9, 5fib, 5fic, 5hqn] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Gorelik, Alexei; Illes, Katalin; Superti-Furga, Giulio; Nagar, Bhushan (2016). Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. Journal of Biological Chemistry 291(12) , 6376-6385. 10.1074/jbc.m115.711085. [PDB: 5fc1, 5fc6, 5fc7, 5fca, 5fcb] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Gruninger, Robert J.; Cote, Chris; McAllister, Tim A.; Abbott, D. Wade (2016). Contributions of a unique β-clamp to substrate recognition illuminates the molecular basis of exolysis in ferulic acid esterases. Biochemical Journal 473(7) , 839-849. 10.1042/bj20151153. [PDB: 5cxu, 5cxx] |
CMCF-ID |
Peer-Reviewed Article |
Agriculture |
Hackos, David H.; Lupardus, Patrick J.; Grand, Teddy; Chen, Yelin; Wang, Tzu-Ming et al. (2016). Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron 89(5) , 983-999. 10.1016/j.neuron.2016.01.016. [PDB: 5h8h] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Haji-Ghassemi, Omid; Gilbert, Michel; Spence, Jenifer; Schur, Melissa J.; Parker, Matthew J. et al. (2016). Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin. Journal of Biological Chemistry 291(46) , 24085-24095. 10.1074/jbc.m116.750463. [PDB: 5kxb, 5kxc, 5kxd, 5kxe] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Hendsbee, Arthur D.; Sun, Jon-Paul; Law, Wai Kit; Yan, He; Hill, Ian G. et al. (2016). Synthesis, Self-Assembly, and Solar Cell Performance of N-Annulated Perylene Diimide Non-Fullerene Acceptors. Chemistry of Materials 28(19) , 7098-7109. 10.1021/acs.chemmater.6b03292. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Materials |
Hewitt, Stephen Nakazawa; Dranow, David M.; Horst, Benjamin G.; Abendroth, Jan A.; Forte, Barbara et al. (2016). Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. ACS Infectious Diseases 3(1) , 34-44. 10.1021/acsinfecdis.6b00078. [PDB: 4wi1, 5ifu] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Hobbs, Joanne K.; Lee, Seunghyae M.; Robb, Melissa; Hof, Fraser; Barr, Christopher et al. (2016). KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate. Proceedings of the National Academy of Sciences of the United States of America 113(22) , 6188-6193. 10.1073/pnas.1524214113. [PDB: 5fpx, 5fpz] |
CMCF-ID |
Peer-Reviewed Article |
Materials |
Hughes, Scott J.; Antoshchenko, Tetyana; Chen, Yun; Lu, Hua; Pizarro, Juan C. et al. (2016). Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs. PLoS ONE 11(5) , e0154862. 10.1371/journal.pone.0154862. [PDB: 5evz, 5ex5, 5exw, 5f0x, 5f2r] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Hughes, Scott J.; Barnard, Leanne; Mottaghi, Katayoun; Tempel, Wolfram; Antoshchenko, Tetyana et al. (2016). Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. ACS Infectious Diseases 2(9) , 627-641. 10.1021/acsinfecdis.6b00090. [PDB: 5jic] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Jha, Vikash; Bian, Chuanbing; Xing, Guangxin; Ling, Hong (2016). Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ. Nucleic Acids Research 44(10) , 4957-4967. 10.1093/nar/gkw204. [PDB: 4u6p, 4u7c] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Johnson, Troy A.; Mcleod, Matthew J.; Holyoak, Todd (2016). Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry 55(3) , 575-587. 10.1021/acs.biochem.5b01215. [PDB: 5fh0, 5fh1, 5fh2] |
CMCF-ID |
Peer-Reviewed Article |
Health |
Jones, Michael D.; Chan, Anson C. K.; Nomellini, John F.; Murphy, Michael E. P.; Smit, John et al. (2016). Surface-layer protein fromCaulobacter crescentus: expression, purification and X-ray crystallographic analysis. Acta Crystallographica Section F:Structural Biology Communications 72(9) , 677-680. 10.1107/s2053230x16011638. |
CMCF-ID |
Peer-Reviewed Article |
Health |