Publication Beamlines Strategic Pillar
Borsari, Chiara; Keles, Erhan; McPhail, Jacob A.; Schaefer, Alexander; Sriramaratnam, Rohitha et al. (2022). Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα. Journal of the American Chemical Society 144(14) . 10.1021/jacs.1c13568. [PDB: 7r9v, 7r9y] CMCF-ID Health
Bullen, Nathan P.; Sychantha, David; Thang, Stephanie S.; Culviner, Peter H.; Rudzite, Marta et al. (2022). An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs. Molecular Cell 82(18) , 3484-3498.e11. 10.1016/j.molcel.2022.08.015. CMCF-ID Health
Candito, David A.; Simov, Vladimir; Gulati, Anmol; Kattar, Solomon; Chau, Ryan W. et al. (2022). Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease. Journal of Medicinal Chemistry 65(24) , 16801-16817. 10.1021/acs.jmedchem.2c01605. [PDB: 8e80] CMCF-ID Health
Cook, Jonathan D.; Khondker, Adree; Lee, Jeffrey E. (2022). Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies. Communications Biology 5(1) . 10.1038/s42003-022-03235-w. [PDB: 7n04, 7n05, 7n07, 7n08] CMCF-ID Health
Fedoretz-Maxwell, Brooklyn P.; Shin, Catherine H.; MacNeil, Gregory A.; Worrall, Liam J.; Park, Rachel et al. (2022). The Impact of Second Coordination Sphere Methionine-Aromatic Interactions in Copper Proteins. Inorganic Chemistry 61(14) , 5563-5571. 10.1021/acs.inorgchem.2c00030. [PDB: 7tc5] CMCF-BM, CMCF-ID Health
Forrester, Taylor J. B.; Ovchinnikova, Olga G.; Li, Zhixiong; Kitova, Elena N.; Nothof, Jeremy T. et al. (2022). The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step. Nature Communications 13(1) . 10.1038/s41467-022-33988-1. [PDB: 8csb, 8csc, 8csd, 8cse, 8csf] CMCF-BM, CMCF-ID Health
Fortinez, Camille Marie; Bloudoff, Kristjan; Harrigan, Connor; Sharon, Itai; Strauss, Mike et al. (2022). Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module. Nature Communications 13(1) . 10.1038/s41467-022-28221-y. [PDB: 7ly6, 7ly7] CMCF-ID Health
Goedken, Eric R.; Argiriadi, Maria A.; Dietrich, Justin D.; Petros, Andrew M.; Krishnan, Navasona et al. (2022). Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Scientific Reports 12(1) . 10.1038/s41598-022-18760-1. [PDB: 8dyg] CMCF-ID Health
Hallett, Robin M.; Bonfill-Teixidor, Ester; Iurlaro, Raffaella; Arias, Alexandra; Raman, Swetha et al. (2022). Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment. Clinical Cancer Research 29(4) , 791-804. 10.1158/1078-0432.ccr-21-1888. CMCF-ID Agriculture
Kim, Hyeong Jin; Black, Mazzen; Edwards, Ross A.; Peillard-Fiorente, Flora; Panigrahi, Rashmi et al. (2022). Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones. Nature Communications 13(1) . 10.1038/s41467-022-34875-5. [PDB: 7rgt] CMCF-ID Health
Kozlov, Guennadi; Mattijssen, Sandy; Jiang, Jianning; Nyandwi, Samuel; Sprules, Tara et al. (2022). Structural basis of 3′-end poly(A) RNA recognition by LARP1. Nucleic Acids Research 50(16) , 9534-9547. 10.1093/nar/gkac696. [PDB: 7soo, 7sop] CMCF-ID Health
Li, Kunhua; Tokareva, Olena S.; Thomson, Ty M.; Wahl, Sebastian C. T.; Travaline, Tara L. et al. (2022). De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries. Proceedings of the National Academy of Sciences of the United States of America 119(52) . 10.1073/pnas.2210435119. [PDB: 7uwi] CMCF-ID Health
Luan, Xiaodong; Li, Xinming; Li, Yufan; Su, Gengchen; Yin, Wanchao et al. (2022). Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein. Science Bulletin 67(22) , 2327-2335. 10.1016/j.scib.2022.10.021. [PDB: 7xwz] CMCF-ID Health
Naidu, B. Narasimhulu; Patel, Manoj; McAuliffe, Brian; Ding, Bo; Cianci, Christopher et al. (2022). Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs. Journal of Medicinal Chemistry 65(6) , 4949-4971. 10.1021/acs.jmedchem.1c02169. [PDB: 7t9o] CMCF-ID Health
Nguyen, Peter; Eshaque, Rony; Garland, Barbara Anne; Dang, Anthony; Suits, Michael D. L. et al. (2022). Degradation of chondroitin sulfate A by a PUL-like operon in Tannerella forsythia. PLoS ONE 17(9) , e0272904. 10.1371/journal.pone.0272904. [PDB: 8di0, 8di1] CMCF-BM, CMCF-ID Health