Publication Beamlines Strategic Pillar
Kgosisejo, Oarabile; Chen, Jian An; Grochulski, Pawel; Tanaka, Takuji (2017). Crystallographic structure of recombinant Lactococcus lactis prolidase to support proposed structure-function relationships. Biochimica et Biophysica Acta - Proteins and Proteomics 1865(5) , 473-480. 10.1016/j.bbapap.2017.02.004. [PDB: 4zng, 6xmr, 7k3u, 7n02] CMCF-BM, CMCF-ID Health
Crawford, Terry D.; Audia, James E.; Bellon, Steve; Burdick, Daniel J.; Bommi-Reddy, Archana et al. (2017). GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Medicinal Chemistry Letters 8(7) , 737-741. 10.1021/acsmedchemlett.7b00132. [PDB: 5v84] CMCF-ID Health
Zhao, Jianhua; Beyrakhova, Ksenia; Liu, Yao; Alvarez, Claudia P.; Bueler, Stephanie A. et al. (2017). Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathogens 13(6) , e1006394. 10.1371/journal.ppat.1006394. [PDB: 5uf5, 5ufk] CMCF-BM, CMCF-ID Health
Radka, Christopher D.; DeLucas, Lawrence J.; Wilson, Landon S.; Lawrenz, Matthew B.; Perry, Robert D. et al. (2017). Crystal structure ofYersinia pestisvirulence factor YfeA reveals two polyspecific metal-binding sites. Acta Crystallographica Section D: Structural Biology 73(7) , 557-572. 10.1107/s2059798317006349. [PDB: 5uy0, 5uy4, 5uy5, 5uya, 5uyb, 5uyc, 5uyd, 5uye, 5uyf] CMCF-ID Health
Noguchi, Masato; Nomura, Akihiro; Murase, Ken; Doi, Satoki; Yamaguchi, Keishi et al. (2017). Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment. Genes to Cells 22(6) , 535-551. 10.1111/gtc.12494. [PDB: 5x8q] CMCF-ID Health
Zhang, Wei; Bailey-Elkin, Ben A.; Knaap, Robert C. M.; Khare, Baldeep; Dalebout, Tim J. et al. (2017). Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. PLoS Pathogens 13(5) , e1006372. 10.1371/journal.ppat.1006372. [PDB: 5v5g, 5v5h, 5v6a] CMCF-BM, CMCF-ID Health
Li, Zhijie; Han, Kristina; Pak, John E; Satkunarajah, Malathy; Zhou, Dongxia et al. (2017). Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1. Nature Chemical Biology 13(7) . 10.1038/nchembio.2381. [PDB: 5kxh, 5kxq, 5ky0, 5ky2, 5ky3, 5ky4, 5ky5, 5ky7, 5ky8, 5ky9] CMCF-ID Health
Huang, Xin; Chen, Hao; Shaffer, Paul L. (2017). Crystal Structures of Human GlyRα3 Bound to Ivermectin. Structure 25(6) , 945-950. 10.1016/j.str.2017.04.007. [PDB: 5vdi] CMCF-ID Health
McCallum, Matthew; Tammam, Stephanie; Khan, Ahmad; Burrows, Lori L.; Howell, P. Lynne et al. (2017). The molecular mechanism of the type IVa pilus motors. Nature Communications 8(1) . 10.1038/ncomms15091. [PDB: 5tsg, 5tsh] CMCF-ID Health
Yeung, Kap-Sun; Beno, Brett R.; Parcella, Kyle; Bender, John A.; Grant-Young, Katherine A. et al. (2017). Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. Journal of Medicinal Chemistry 60(10) , 4369-4385. 10.1021/acs.jmedchem.7b00328. [PDB: 5pzp] CMCF-ID Health
Tarry, Michael J.; Haque, Asfarul S.; Bui, Khanh Huy; Schmeing, T. Martin (2017). X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture. Structure 25(5) , 783-793.e4. 10.1016/j.str.2017.03.014. [PDB: 5u89] CMCF-ID Health
Sakurada, Isao; Endo, Toshiya; Hikita, Katsuyoshi; Hirabayashi, Tomokazu; Hosaka, Yoshitaka et al. (2017). Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors. Bioorganic and Medicinal Chemistry Letters 27(11) , 2622-2628. 10.1016/j.bmcl.2017.03.002. [PDB: 5tnt] CMCF-ID Health
Fong, Desiree H.; Burk, David L.; Blanchet, Jonathan; Yan, Amy Y.; Berghuis, Albert M. et al. (2017). Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure 25(5) , 750-761. 10.1016/j.str.2017.03.007. [PDB: 5igh, 5igi, 5igj, 5igp, 5igr, 5igs, 5igt, 5igu, 5igv, 5igy, 5igz, 5ih0, 5ih1, 5iwu] CMCF-ID Health
Machuqueiro, Miguel; Victor, Bruno; Switala, Jacek; Villanueva, Jacylyn; Rovira, Carme et al. (2017). The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine. Biochemistry 56(17) , 2271-2281. 10.1021/acs.biochem.6b01276. [PDB: 5kq0, 5kq2, 5kq3, 5kq6, 5kqh, 5kqi, 5kqk, 5ksf, 5ksk, 5syu, 5syv, 5syw, 5txq, 5v4o, 5v53] CMCF-ID Materials
Gorelik, Alexei; Liu, Fangyu; Illes, Katalin; Nagar, Bhushan (2017). Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition. Journal of Biological Chemistry 292(17) , 7087-7094. 10.1074/jbc.m116.769273. [PDB: 5tcd, 5udy] CMCF-ID Health