Publication Beamlines Strategic Pillar
Boniecki, Michal T.; Freibert, Sven A.; Mühlenhoff, Ulrich; Lill, Roland; Cygler, Miroslaw et al. (2017). Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nature Communications 8(1) . 10.1038/s41467-017-01497-1. [PDB: 5wgb, 5wkp, 5wlw] CMCF-ID Health
Ebeling, Julia; Fünfhaus, Anne; Knispel, Henriette; Krska, Daniel; Ravulapalli, Ravikiran et al. (2017). Characterization of the toxin Plx2A, a RhoA-targeting ADP-ribosyltransferase produced by the honey bee pathogenPaenibacillus larvae. Environmental Microbiology 19(12) , 5100-5116. 10.1111/1462-2920.13989. CMCF-ID Agriculture
Ereño-Orbea, June; Sicard, Taylor; Cui, Hong; Mazhab-Jafari, Mohammad T.; Benlekbir, Samir et al. (2017). Molecular basis of human CD22 function and therapeutic targeting. Nature Communications 8(1) . 10.1038/s41467-017-00836-6. [PDB: 5vkj, 5vkk, 5vkm, 5vl3] CMCF-BM, CMCF-ID Health
Gorelik, Alexei; Randriamihaja, Antsa; Illes, Katalin; Nagar, Bhushan (2017). A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP 5. FEBS Journal 284(21) , 3718-3726. 10.1111/febs.14266. [PDB: 5vem, 5ven] CMCF-ID Health
Grochulski, Pawel; Fodje, Michel; Labiuk, Shaun; Wysokinski, Tomasz W.; Belev, George et al. (2017). Review of Canadian Light Source facilities for biological applications. Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 411, 17-21. 10.1016/j.nimb.2017.01.065. BIOXAS, BMIT-BM, BMIT-ID, CMCF-BM, CMCF-ID, MID-IR Health
Kozlov, Guennadi; Wong, Kathy; Gehring, Kalle (2017). Crystal structure of the Legionella effector Lem22. Proteins: Structure. Function and Bioinformatics 86(2) , 263-267. 10.1002/prot.25427. [PDB: 5wd8] CMCF-ID Health
Park, Jaeok; Rodionov, Dmitry; De Schutter, Joris W.; Lin, Yih-Shyan; Tsantrizos, Youla S. et al. (2017). Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE 12(10) , e0186447. 10.1371/journal.pone.0186447. [PDB: 4nfi, 4nfj, 4nfk] CMCF-ID Health
Rai, Ganesha; Brimacombe, Kyle R.; Mott, Bryan T.; Urban, Daniel J.; Hu, Xin et al. (2017). Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of Medicinal Chemistry 60(22) , 9184-9204. 10.1021/acs.jmedchem.7b00941. [PDB: 5w8h, 5w8j] CMCF-ID Health
Riggs, Jennifer R.; Nagy, Mark; Elsner, Jan; Erdman, Paul; Cashion, Dan et al. (2017). The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. Journal of Medicinal Chemistry 60(21) , 8989-9002. 10.1021/acs.jmedchem.7b01223. [PDB: 6b4w] CMCF-ID Health
Scally, Stephen W.; McLeod, Brandon; Bosch, Alexandre; Miura, Kazutoyo; Liang, Qi et al. (2017). Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25. Nature Communications 8(1) . 10.1038/s41467-017-01924-3. [PDB: 6azz, 6b08, 6b0a, 6b0e, 6b0g, 6b0h] CMCF-ID Health
Scally, Stephen W.; Murugan, Rajagopal; Bosch, Alexandre; Triller, Gianna; Costa, Giulia et al. (2017). Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection. Journal of Experimental Medicine 215(1) , 63-75. 10.1084/jem.20170869. [PDB: 6b0s, 6b0w] CMCF-ID Health
Siu, Tony; Brubaker, Jason; Fuller, Peter; Torres, Luis; Zeng, Hongbo et al. (2017). The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. Journal of Medicinal Chemistry 60(23) , 9676-9690. 10.1021/acs.jmedchem.7b01135. [PDB: 5wo4] CMCF-ID Health
Sun, Luxin; Huang, Yuhao; Edwards, Ross A.; Yang, Sukmin; Blackford, Andrew N. et al. (2017). Structural Insight into BLM Recognition by TopBP1. Structure 25(10) , 1582-1588.e3. 10.1016/j.str.2017.08.005. [PDB: 5u6k] CMCF-ID Health
Triller, Gianna; Scally, Stephen W.; Costa, Giulia; Pissarev, Maria; Kreschel, Cornelia et al. (2017). Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity 47(6) , 1197-1209.e10. 10.1016/j.immuni.2017.11.007. [PDB: 5bk0, 5bk3, 5bk5, 6azm, 6azx] CMCF-ID Health
Wong, Alan H. M.; Tomlinson, Aidan C. A.; Zhou, Dongxia; Satkunarajah, Malathy; Chen, Kevin et al. (2017). Receptor-binding loops in alphacoronavirus adaptation and evolution. Nature Communications 8(1) . 10.1038/s41467-017-01706-x. [PDB: 6atk] CMCF-ID Health