Publication Beamlines Strategic Pillar
Wu, Wen-Lian; Hao, Jinsong; Domalski, Martin; Burnett, Duane A.; Pissarnitski, Dmitri et al. (2016). Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Medicinal Chemistry Letters 7(5) , 498-501. 10.1021/acsmedchemlett.6b00027. [PDB: 5i7u] CMCF-ID Health
Shaw, Alice T.; Friboulet, Luc; Leshchiner, Ignaty; Gainor, Justin F.; Bergqvist, Simon et al. (2016). Resensitization to Crizotinib by the LorlatinibALKResistance Mutation L1198F. New England Journal of Medicine 374(1) , 54-61. 10.1056/nejmoa1508887. [PDB: 5a9u, 5aac] CMCF-ID Health
Taylor, Alexander M.; Côté, Alexandre; Hewitt, Michael C.; Pastor, Richard; Leblanc, Yves et al. (2016). Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). ACS Medicinal Chemistry Letters 7(5) , 531-536. 10.1021/acsmedchemlett.6b00075. [PDB: 5i83, 5i86] CMCF-ID Health
Gruninger, Robert J.; Cote, Chris; McAllister, Tim A.; Abbott, D. Wade (2016). Contributions of a unique β-clamp to substrate recognition illuminates the molecular basis of exolysis in ferulic acid esterases. Biochemical Journal 473(7) , 839-849. 10.1042/bj20151153. [PDB: 5cxu, 5cxx] CMCF-ID Agriculture
Bloudoff, Kristjan; Alonzo, Diego A.; Schmeing, T. Martin (2016). Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases. Cell Chemical Biology 23(3) , 331-339. 10.1016/j.chembiol.2016.02.012. [PDB: 5du9, 5dua] CMCF-ID Health
Jha, Vikash; Bian, Chuanbing; Xing, Guangxin; Ling, Hong (2016). Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ. Nucleic Acids Research 44(10) , 4957-4967. 10.1093/nar/gkw204. [PDB: 4u6p, 4u7c] CMCF-ID Health
Getlik, Matthäus; Smil, David; Zepeda-Velázquez, Carlos; Bolshan, Yuri; Poda, Gennady et al. (2016). Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Journal of Medicinal Chemistry 59(6) , 2478-2496. 10.1021/acs.jmedchem.5b01630. [PDB: 5eam, 5eap] CMCF-ID Health
Malia, Thomas J.; Teplyakov, Alexey; Ernst, Robin; Wu, Sheng‐Jiun; Lacy, Eilyn R. et al. (2016). Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti‐tau antibody AT8. Proteins: Structure. Function and Bioinformatics 84(4) , 427-434. 10.1002/prot.24988. [PDB: 5e2w] CMCF-ID Health
Skovpen, Yulia V.; Conly, Cuylar J. T.; Sanders, David A. R.; Palmer, David R. J. (2016). Biomimetic Design Results in a Potent Allosteric Inhibitor of Dihydrodipicolinate Synthase from Campylobacter jejuni. Journal of the American Chemical Society 138(6) , 2014-2020. 10.1021/jacs.5b12695. [PDB: 5f1u, 5f1v] CMCF-ID Health
Das, Samir; Gilchrist, John; Bosmans, Frank; Van Petegem, Filip (2016). Binary architecture of the Nav1.2-β2 signaling complex. eLife 5, e10960. 10.7554/elife.10960. [PDB: 5feb] CMCF-ID Health
Rutaganira, Florentine U.; Fowler, Melissa L.; McPhail, Jacob A.; Gelman, Michael A.; Nguyen, Khanh et al. (2016). Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. Journal of Medicinal Chemistry 59(5) , 1830-1839. 10.1021/acs.jmedchem.5b01311. [PDB: 5euq] CMCF-ID Health
Hackos, David H.; Lupardus, Patrick J.; Grand, Teddy; Chen, Yelin; Wang, Tzu-Ming et al. (2016). Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron 89(5) , 983-999. 10.1016/j.neuron.2016.01.016. [PDB: 5h8h] CMCF-ID Health
Wahba, Haytham M.; Lecoq, Lauriane; Stevenson, Michael; Mansour, Ahmed; Cappadocia, Laurent et al. (2016). Structural and Biochemical Characterization of a Copper-Binding Mutant of the Organomercurial Lyase MerB: Insight into the Key Role of the Active Site Aspartic Acid in Hg–Carbon Bond Cleavage and Metal Binding Specificity. Biochemistry 55(7) , 1070-1081. 10.1021/acs.biochem.5b01298. [PDB: 5c17] CMCF-ID Environment
Sack, John S.; Gao, Mian; Kiefer, Susan E.; Myers, Joseph E.; Newitt, John A. et al. (2016). Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor. Acta Crystallographica Section F:Structural Biology Communications 72(2) , 129-134. 10.1107/s2053230x15024747. [PDB: 5es1] CMCF-ID Health
Kobylarz, Marek J.; Grigg, Jason C.; Liu, Yunan; Lee, Mathew S. F.; Heinrichs, David E. et al. (2016). Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis. Biochemistry 55(6) , 927-939. 10.1021/acs.biochem.5b01045. [PDB: 5d84] CMCF-BM, CMCF-ID Health