Publication Beamlines Strategic Pillar
Almawi, Ahmad W; Scotland, Michelle K; Randall, Justin R; Liu, Linda; Martin, Heather K et al. (2019). Binding of the regulatory domain of MutL to the sliding β-clamp is species specific. Nucleic Acids Research 47(9) . 10.1093/nar/gkz115. [PDB: 6e8d, 6e8e] CMCF-BM, CMCF-ID Health
Chong, Pek Y.; Shotwell, J. Brad; Miller, John; Price, Daniel J.; Maynard, Andy et al. (2019). Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. Journal of Medicinal Chemistry 62(7) , 3254-3267. 10.1021/acs.jmedchem.8b01719. [PDB: 6mvo] CMCF-ID Health
Duan, James J.-W.; Lu, Zhonghui; Jiang, Bin; Stachura, Sylwia; Weigelt, Carolyn A. et al. (2019). Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists. ACS Medicinal Chemistry Letters 10(3) , 367-373. 10.1021/acsmedchemlett.9b00010. [PDB: 6nx1] CMCF-ID Health
Gytz, Heidi; Liang, Jason; Liang, Yingke; Gorelik, Alexei; Illes, Katalin et al. (2019). The structure of mammalian β‐mannosidase provides insight into β‐mannosidosis and nystagmus. FEBS Journal 286(7) . 10.1111/febs.14731. [PDB: 6ddt, 6ddu] CMCF-ID Health
Liu, Yanli; Qin, Su; Chen, Tsai-Yu; Lei, Ming; Dhar, Shilpa S. et al. (2019). Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Nature Communications 10(1) . 10.1038/s41467-018-07906-3. [PDB: 6mlc] CMCF-ID Health
Mangat, Chand S.; Vadlamani, Grishma; Holicek, Viktor; Chu, Mitchell; Larmour, Veronica L. C. et al. (2019). Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam. Antimicrobial Agents and Chemotherapy 63(4) . 10.1128/aac.02112-18. [PDB: 6mk6] CMCF-BM, CMCF-ID Health
McDougall, Matthew; Francisco, Olga; Harder-Viddal, Candice; Roshko, Roy; Heide, Fabian et al. (2019). Proteinaceous Nano container Encapsulate Polycyclic Aromatic Hydrocarbons. Scientific Reports 9(1) . 10.1038/s41598-018-37323-x. CMCF-ID Health
Raman, Swetha; Beilschmidt, Melissa; To, Minh; Lin, Kevin; Lui, Francine et al. (2019). Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America 116(14) , 6812-6817. 10.1073/pnas.1817246116. [PDB: 6o39, 6o3a] CMCF-ID Health
Ryan, Patrick; Forrester, Taylor J.B.; Wroblewski, Charles; Kenney, Tristan M.G.; Kitova, Elena N. et al. (2019). The small RbcS-like domains of the β-carboxysome structural protein CcmM bind RubisCO at a site distinct from that binding the RbcS subunit. Journal of Biological Chemistry 294(8) , 2593-2603. 10.1074/jbc.ra118.006330. [PDB: 6mr1] CMCF-ID Agriculture
Sengupta, Shomit; Giaime, Emilie; Narayan, Sridhar; Hahm, Seung; Howell, Jessica et al. (2019). Discovery of NV-5138, the first selective Brain mTORC1 activator. Scientific Reports 9(1) , 4107. 10.1038/s41598-019-40693-5. [PDB: 6n0m] CMCF-ID Health
Simonetta, Kyle R.; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E.; Padovani, Chris et al. (2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 10(1) , 1402. 10.1038/s41467-019-09358-9. [PDB: 6m91, 6m92, 6m93, 6m94] CMCF-ID Health
Spergel, Steven H.; Mertzman, Michael E.; Kempson, James; Guo, Junqing; Stachura, Sylwia et al. (2019). Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Medicinal Chemistry Letters 10(3) , 306-311. 10.1021/acsmedchemlett.8b00508. [PDB: 6ny4] CMCF-ID Health
Wei, Yong; Xiong, Zi Jian; Li, Jun; Zou, Chunxia; Cairo, Christopher W. et al. (2019). Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters. Communications Biology 2(1) . 10.1038/s42003-018-0262-9. [PDB: 6e7o] CMCF-ID Health
White, Brandy; Huh, Ian; Brooks, Cory L. (2019). Structure of a VHH isolated from a naïve phage display library. BMC Research Notes 12(1) . 10.1186/s13104-019-4197-0. [PDB: 6dyx] CMCF-ID Health
Whitesell, Luke; Robbins, Nicole; Huang, David S.; McLellan, Catherine A.; Shekhar-Guturja, Tanvi et al. (2019). Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications 10(1) , 402. 10.1038/s41467-018-08248-w. [PDB: 6cjl, 6cjp] CMCF-ID Health