Zhao, Jianhua; Beyrakhova, Ksenia; Liu, Yao; Alvarez, Claudia P.; Bueler, Stephanie A. et al. (2017). Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathogens 13(6) , e1006394. 10.1371/journal.ppat.1006394. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Zhang, Wei; Bailey-Elkin, Ben A.; Knaap, Robert C. M.; Khare, Baldeep; Dalebout, Tim J. et al. (2017). Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. PLoS Pathogens 13(5) , e1006372. 10.1371/journal.ppat.1006372. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Yang, Yuhong; Xu, Yuanyuan; Yue, Yuan; Wang, Heng; Cui, Yumeng et al. (2021). Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. ACS Chemical Biology 17(1) , 39-53. 10.1021/acschembio.1c00394. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Yamniuk, Aaron P.; Suri, Anish; Krystek, Stanley R.; Tamura, James; Ramamurthy, Vidhyashankar et al. (2016). Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope. Journal of Molecular Biology 428(14) , 2860-2879. 10.1016/j.jmb.2016.05.014. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Xu, Shangyi; Grochulski, Pawel; Tanaka, Takuji (2024). Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase. Biochimica et Biophysica Acta - Proteins and Proteomics 1872(3) , 141000. 10.1016/j.bbapap.2024.141000. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Wysokinski, T.W.; Ianowski, J.P.; Luan, X.; Belev, G.; Miller, D. et al. (2016). BMIT facility at the Canadian Light Source: Advances in X-ray phase-sensitive imaging. Physica Medica 32(12) , 1753-1758. 10.1016/j.ejmp.2016.07.090. |
BMIT-BM, BMIT-ID |
Peer-Reviewed Article |
Health |
Wysokinski, Tomasz W.; Chapman, Dean; Adams, Gregg; Renier, Michel; Suortti, Pekka et al. (2015). Beamlines of the biomedical imaging and therapy facility at the Canadian light source – part 3. Nuclear Instruments and Methods in Physics Research. Section A: Accelerators. Spectrometers. Detectors and Associated Equipment 775, 1-4. 10.1016/j.nima.2014.11.088. |
BMIT-BM, BMIT-ID |
Peer-Reviewed Article |
Health |
Wrobleski, Stephen T.; Moslin, Ryan; Lin, Shuqun; Zhang, Yanlei; Spergel, Steven et al. (2019). Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. Journal of Medicinal Chemistry 62(20) . 10.1021/acs.jmedchem.9b00444. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Whitesell, Luke; Robbins, Nicole; Huang, David S.; McLellan, Catherine A.; Shekhar-Guturja, Tanvi et al. (2019). Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications 10(1) , 402. 10.1038/s41467-018-08248-w. |
CMCF-ID |
Peer-Reviewed Article |
Health |
White, E. Railey; Sun, Luxin; Ma, Zhong; Beckta, Jason M.; Danzig, Brittany A. et al. (2015). Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain. ACS Chemical Biology 10(5) , 1198-1208. 10.1021/cb500757u. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Wahba, Haytham M.; Stevenson, Michael J.; Mansour, Ahmed; Sygusch, Jurgen; Wilcox, Dean E. et al. (2017). Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon–Metal Bond Cleavage. Journal of the American Chemical Society 139(2) , 910-921. 10.1021/jacs.6b11327. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Wagner, Florence F.; Benajiba, Lina; Campbell, Arthur J.; Weïwer, Michel; Sacher, Joshua R. et al. (2018). Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Science Translational Medicine 10(431) , eaam8460. 10.1126/scitranslmed.aam8460. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Vuong, Wayne; Fischer, Conrad; Khan, Muhammad Bashir; van Belkum, Marco J.; Lamer, Tess et al. (2021). Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies. European Journal of Medicinal Chemistry 222, 113584. 10.1016/j.ejmech.2021.113584. |
CMCF-BM |
Peer-Reviewed Article |
Health |
Von Dwingelo, Juanita; Chung, Ivy Yeuk Wah; Price, Christopher T.; Li, Lei; Jones, Snake et al. (2019). Interaction of the Ankyrin H Core Effector of
Legionella
with the Host LARP7 Component of the 7SK snRNP Complex. mBio 10(4) , e01942-19. 10.1128/mbio.01942-19. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Volkers, Gesa; Worrall, Liam J; Kwan, David H; Yu, Ching-Ching; Baumann, Lars et al. (2015). Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Nature Structural and Molecular Biology 22(8) , 627-635. 10.1038/nsmb.3060. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |