Publication Beamlines Strategic Pillar
Blanchard, Peter E.R.; Van Loon, Lisa L.; Reid, Joel W.; Cutler, Jeffrey N.; Rowson, John et al. (2017). Investigating arsenic speciation in the JEB Tailings Management Facility at McClean Lake, Saskatchewan using X-ray absorption spectroscopy. Chemical Geology 466, 617-626. 10.1016/j.chemgeo.2017.07.014. CMCF-BM, HXMA Environment
Duclos, Franck; Abell, Lynn M.; Harden, David G.; Pike, Kristen; Nowak, Kimberly et al. (2017). Triazolopyrimidines identified as reversible myeloperoxidase inhibitors. MedChemComm 8(11) , 2093-2099. 10.1039/c7md00268h. [PDB: 5wdj] CMCF-ID Health
Eastman, Kyle J.; Parcella, Kyle; Yeung, Kap-Sun; Grant-Young, Katharine A.; Zhu, Juliang et al. (2017). The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. MedChemComm 8(4) , 796-806. 10.1039/c6md00636a. [PDB: 5twn] CMCF-ID Health
Hynes, John; Wu, Hong; Kempson, James; Duan, James J.-W.; Lu, Zhonghui et al. (2017). Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(14) , 3101-3106. 10.1016/j.bmcl.2017.05.043. [PDB: 5vo6] CMCF-ID Health
Planken, Simon; Behenna, Douglas C.; Nair, Sajiv K.; Johnson, Theodore O.; Nagata, Asako et al. (2017). Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR. Journal of Medicinal Chemistry 60(7) , 3002-3019. 10.1021/acs.jmedchem.6b01894. [PDB: 5ugc] CMCF-ID Health
Rai, Ganesha; Brimacombe, Kyle R.; Mott, Bryan T.; Urban, Daniel J.; Hu, Xin et al. (2017). Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of Medicinal Chemistry 60(22) , 9184-9204. 10.1021/acs.jmedchem.7b00941. [PDB: 5w8h, 5w8j] CMCF-ID Health
Riggs, Jennifer R.; Nagy, Mark; Elsner, Jan; Erdman, Paul; Cashion, Dan et al. (2017). The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. Journal of Medicinal Chemistry 60(21) , 8989-9002. 10.1021/acs.jmedchem.7b01223. [PDB: 6b4w] CMCF-ID Health
Sakurada, Isao; Endo, Toshiya; Hikita, Katsuyoshi; Hirabayashi, Tomokazu; Hosaka, Yoshitaka et al. (2017). Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors. Bioorganic and Medicinal Chemistry Letters 27(11) , 2622-2628. 10.1016/j.bmcl.2017.03.002. [PDB: 5tnt] CMCF-ID Health
Siu, Tony; Brubaker, Jason; Fuller, Peter; Torres, Luis; Zeng, Hongbo et al. (2017). The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. Journal of Medicinal Chemistry 60(23) , 9676-9690. 10.1021/acs.jmedchem.7b01135. [PDB: 5wo4] CMCF-ID Health
Stanger, Frédéric V.; de Beer, Tjaart A.P.; Dranow, David M.; Schirmer, Tilman; Phan, Isabelle et al. (2017). The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook. Structure 25(1) , 203-211. 10.1016/j.str.2016.10.010. [PDB: 4yk1] CMCF-ID Health
Xiong, Yumei; Walker, Kenneth; Min, Xiaoshan; Hale, Clarence; Tran, Thanhvien et al. (2017). Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys. Science Translational Medicine 9(412) , eaan8732. 10.1126/scitranslmed.aan8732. [PDB: 5vt2] CMCF-ID Health
Yeung, Kap-Sun; Beno, Brett R.; Parcella, Kyle; Bender, John A.; Grant-Young, Katherine A. et al. (2017). Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. Journal of Medicinal Chemistry 60(10) , 4369-4385. 10.1021/acs.jmedchem.7b00328. [PDB: 5pzp] CMCF-ID Health
Gayda, Susan; Longenecker, Kenton L.; Judge, Russell A.; Swift, Kerry M.; Manoj, Sharmila et al. (2016). Three-dimensional structure, binding, and spectroscopic characteristics of the monoclonal antibody 43.1 directed to the carboxyphenyl moiety of fluorescein. Biopolymers 105(4) , 234-243. 10.1002/bip.22801. [PDB: 5dyo] CMCF-ID Health
Hackos, David H.; Lupardus, Patrick J.; Grand, Teddy; Chen, Yelin; Wang, Tzu-Ming et al. (2016). Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron 89(5) , 983-999. 10.1016/j.neuron.2016.01.016. [PDB: 5h8h] CMCF-ID Health
Malia, Thomas J.; Teplyakov, Alexey; Ernst, Robin; Wu, Sheng‐Jiun; Lacy, Eilyn R. et al. (2016). Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti‐tau antibody AT8. Proteins: Structure. Function and Bioinformatics 84(4) , 427-434. 10.1002/prot.24988. [PDB: 5e2w] CMCF-ID Health