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| Ferri, Elena; Le Thomas, Adrien; Wallweber, Heidi Ackerly; Day, Eric S.; Walters, Benjamin T. et al. (2020). Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands. Nature Communications 11(1) . 10.1038/s41467-020-19974-5. [PDB: 6w3b, 6w3c] |
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| Lord, D.M.; Zhou, Y.F. (2020). 2xVH Fab. Protein Data Bank: 7jkb. |
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PDB Deposition |
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| Ramasubramanian, Anusuya; Tennyson, Rachel; Magnay, Maureen; Kathuria, Sagar; Travaline, Tara et al. (2020). Bringing the Heavy Chain to Light: Creating a Symmetric, Bivalent IgG-Like Bispecific. Antibodies 9(4) , 62. 10.3390/antib9040062. [PDB: 7jkb] |
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| Hu, Zilun; Wang, Cailan; Glunz, Peter W.; Li, Julia; Cheadle, Nathan L. et al. (2020). Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies. Bioorganic and Medicinal Chemistry Letters 30(21) , 127495. 10.1016/j.bmcl.2020.127495. [PDB: 7jou] |
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| Wei, R.; Zhou, Y.F. (2020). NNAS Fc mutant. Protein Data Bank: 6x3i. |
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PDB Deposition |
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| Zhou, Qun; Jaworski, Julie; Zhou, Yanfeng; Valente, Delphine; Cotton, Joanne et al. (2020). Engineered Fc-glycosylation switch to eliminate antibody effector function. mAbs 12(1) , 1814583. 10.1080/19420862.2020.1814583. [PDB: 6x3i] |
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| Wang, F.; Lv, Z.; Cheng, W.; Lin, D.; Miao, Q. et al. (2020). The Crystal Structure of human PHGDH from Biortus.. Protein Data Bank: 7cvp. |
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PDB Deposition |
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| Palte, Rachel L.; Schneider, Sebastian E.; Altman, Michael D.; Hayes, Robert P.; Kawamura, Shuhei et al. (2020). Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). ACS Medicinal Chemistry Letters 11(9) . 10.1021/acsmedchemlett.9b00525. [PDB: 6uxy] |
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| Wang, F.; Lin, D.; Cheng, W.; Bao, X.; Zhu, B. et al. (2020). The Crystal Structure of human LDHA from Wuxi Biortus.. Protein Data Bank: 6zzr. |
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| Parthasarathy, G.; Soisson, S.M. (2020). Sortilin-Progranulin Interaction With Compound 17. Protein Data Bank: 6x48. |
CMCF-ID |
PDB Deposition |
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| Parthasarathy, G.; Soisson, S.M. (2020). Sortilin-Progranulin Interaction With Compound 2. Protein Data Bank: 6x3l. |
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| Stachel, Shawn J.; Ginnetti, Anthony T.; Johnson, Scott A.; Cramer, Paige; Wang, Yi et al. (2020). Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorganic and Medicinal Chemistry Letters 30(17) , 127403. 10.1016/j.bmcl.2020.127403. [PDB: 6x3l, 6x48] |
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| Chung, Chun-wa; Dai, Han; Fernandez, Esther; Tinworth, Christopher P.; Churcher, Ian et al. (2020). Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chemical Biology 15(9) . 10.1021/acschembio.0c00266. [PDB: 6zhc] |
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| Harikrishnan, Lalgudi S.; Gill, Patrice; Kamau, Muthoni G.; Qin, Lan-Ying; Ruan, Zheming et al. (2020). Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORĪ³t) agonists. Bioorganic and Medicinal Chemistry Letters 30(12) , 127204. 10.1016/j.bmcl.2020.127204. [PDB: 6xae] |
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