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| Jarvis, Thale C.; Davies, Douglas R.; Hisaminato, Akihiko; Resnicow, Daniel I.; Gupta, Shashi et al. (2015). Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor. Structure 23(7) , 1293-1304. 10.1016/j.str.2015.03.027. [PDB: 4zbn] |
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| Khan, J.A. (2019). CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound. Protein Data Bank: 6nzr. |
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| Khan, J.A. (2019). CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound. Protein Data Bank: 6nzq. |
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| Wrobleski, Stephen T.; Moslin, Ryan; Lin, Shuqun; Zhang, Yanlei; Spergel, Steven et al. (2019). Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. Journal of Medicinal Chemistry 62(20) . 10.1021/acs.jmedchem.9b00444. [PDB: 6nzq, 6nzr] |
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| Edwards, T.E.; Abendroth, J.; Safford, K.; Chun, L. (2019). Crystal structure of KIT1 in complex with DP2976 via co-crystallization. Protein Data Bank: 6mob. |
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| Smith, Bryan D.; Kaufman, Michael D.; Lu, Wei-Ping; Gupta, Anu; Leary, Cynthia B. et al. (2019). Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants. Cancer Cell 35(5) , 738-751.e9. 10.1016/j.ccell.2019.04.006. [PDB: 6mob] |
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| Sack, J. (2019). Crystal structure of RAR-related orphan receptor C (NHIS-RORGT(244-487)-L6-SRC1(678-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor. Protein Data Bank: 6p9f. |
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| Lu, Zhonghui; Duan, James J.-W.; Xiao, Haiyun; Neels, James; Wu, Dauh-Rurng et al. (2019). Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists. Bioorganic and Medicinal Chemistry Letters 29(16) . 10.1016/j.bmcl.2019.06.036. [PDB: 6p9f] |
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| Bryan, Marian C.; Drobnick, Joy; Gobbi, Alberto; Kolesnikov, Aleksandr; Chen, Yongsheng et al. (2019). Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. Journal of Medicinal Chemistry 62(13) . 10.1021/acs.jmedchem.9b00439. [PDB: 6o9d] |
CMCF-ID |
Peer-Reviewed Article |
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| Yu, C.; Drobnick, J.; Bryan, M.C.; Kiefer, J.; Lupardus, P.J. et al. (2019). Structure of the IRAK4 kinase domain with compound 5. Protein Data Bank: 6o9d. |
CMCF-ID |
PDB Deposition |
Health |
| Sack, J.S. (2019). Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor. Protein Data Bank: 6ny4. |
CMCF-ID |
PDB Deposition |
Health |
| Spergel, Steven H.; Mertzman, Michael E.; Kempson, James; Guo, Junqing; Stachura, Sylwia et al. (2019). Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Medicinal Chemistry Letters 10(3) , 306-311. 10.1021/acsmedchemlett.8b00508. [PDB: 6ny4] |
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Peer-Reviewed Article |
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| Riggs, Jennifer R.; Elsner, Jan; Cashion, Dan; Robinson, Dale; Tehrani, Lida et al. (2019). Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy. Journal of Medicinal Chemistry 62(9) , 4401-4410. 10.1021/acs.jmedchem.8b01869. [PDB: 6n6o] |
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Peer-Reviewed Article |
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| Fischmann, T.O. (2019). Murine PI3K delta kinsae domain - cpd 1. Protein Data Bank: 6mul. |
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